Table 4.
Average number of msp-7 gene synonymous divergence per synonymous site (K S ) and non-synonymous divergence per non-synonymous site (K N )
| n | Gene | 5′ end | Central | 3′ end | Full-length gene | ||||
|---|---|---|---|---|---|---|---|---|---|
| Worldwide isolates | KS(SE) | KN(SE) | KS(SE) | KN(SE) | KS(SE) | KN(SE) | KS(SE) | KN(SE) | |
| 36 | msp-7E | 0.0746 (0.0156)• | 0.0126 (0.0034) | 0.0813 (0.0185) | 0.1976 (0.0191)• | 0.0980 (0.0163)• | 0.0299 (0.0056) | 0.0833 (0.0092) | 0.0676 (0.0066) |
| 42 | msp-7F | 0.0098 (0.0023)† | 0.0047 (0.0009) | 0.0146 (0.0029) | 0.0141 (0.0022) | 0.0086 (0.0022) | 0.0100 (0.0022) | 0.0110 (0.0014) | 0.0096 (0.0010) |
| 37 | msp-7L | 0.0140 (0.0031)‡ | 0.0092 (0.0017) | 0.0172 (0.0035) | 0.0149 (0.0020) | 0.0111 (0.0025)‡ | 0.0070 (0.0013) | 0.0139 (0.0017)* | 0.0102 (0.0010) |
| Colombian isolates | |||||||||
| 32 | msp-7E | 0.0755 (0.0151)• | 0.0128 (0.0032) | 0.0808 (0.0183) | 0.1963 (0.0191)• | 0.0982 (0.0156)• | 0.0305 (0.0053) | 0.0834 (0.0089) | 0.0676 (0.0065) |
| 37 | msp-7F | 0.0111 (0.0027)† | 0.0053 (0.0011) | 0.0165 (0.0033) | 0.0156 (0.0023) | 0.0098 (0.0025) | 0.0110 (0.0022) | 0.0125 (0.0016) | 0.0107 (0.0011) |
| 32 | msp-7L | 0.0156 (0.0037)‡ | 0.0107 (0.0020) | 0.0199 (0.0041) | 0.0170 (0.0023) | 0.0123 (0.0027)‡ | 0.0081 (0.0015) | 0.0157 (0.0019)* | 0.0118 (0.0011) |
SE: standard error. 5′-end (pvmsp-7E: nucleotide 1–390, pvmsp-7F: nucleotide 1–432, pvmsp-7L: nucleotide 1–381), central (pvmsp-7E: nucleotide 391–747, pvmsp-7F: nucleotide 433–1,053, pvmsp-7L: nucleotide 382–816) and 3′-end (pvmsp-7E: nucleotide 748–1,158, pvmsp-7F: nucleotide 1,054–1,449, pvmsp-7L: nucleotide 817–1,275). Numbering based on Additional files 4, 9 and 10. ‡: p <0.09, *: p <0.04, †: p <0.02, •: p <0.001.