Table 1.

Examples of contributions of computational systems neurobiology to translational neurology.

Mechanism elucidated	Computational prediction	Supporting experiments	References (Computational/Experiment)
Source of requisite IP3	PIP2 synthesis concurrent with hydrolysis	IP3 production in neuroblastoma cells	Xu et al., 2003/Xu et al., 2003
Purkinje spine electrophysiology	D-type K and class-E Ca channels required	Purkinje neuron current clamp	Miyasho et al., 2001/Miyasho et al., 2001
Biochemical-electrical cross-talk	Emergent cross-signaling properties	Biochemical before electrical changes in SCA2 mice	Brown and Loew, 2012/Hansen et al., 2013
AMPAR all-or-none activation	MAPK-PKC positive feedback loop	Purkinje stimulation by CFs/PFs	Ogasawara et al., 2008/Ogasawara et al., 2008
Local PIP2 sequestration	Fine-tunes coincidence detection	Purkinje stimulation by CFs/PFs	Brown et al., 2008/Wang et al., 2000
Coincidence detection	50–100 ms time window CF before PF	Purkinje stimulation by CFs/PFs	Brown et al., 2008/Sarkisov and Wang, 2008
IP3R1 compensation	IP3R1 downregulation in polyQ disorders with IP3R1 supersensitivity	IP3R1 (and other members of the signaling complex*) downregulation in DLPRA	Brown and Loew, 2012/Suzuki et al., 2012

^*(Supplementary Material, S1 Signaling complex regulation).