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. Author manuscript; available in PMC: 2015 Jan 21.
Published in final edited form as: J Neurosci Res. 2010 Nov 1;88(14):3090–3101. doi: 10.1002/jnr.22458

Fig. 6.

Fig. 6

HIV-1 induced phosphorylation of PDK1 and AKT in HBMEC. CCR5 antibodies and inhibitors of STAT1 and PI3K diminished virus-induced PDK1 and AKT phosphorylation. Exposure of HBMEC to HIV-1 increased phosphorylation of PDK1 at serine-241 (A,D,E) and AKT at threonine-308 (B,C). No phosphorylation of AKT at serine-473 was detected (B). CCR5 antibodies, fludarabine (FLUD), and LY-294002 diminished HIV-induced phosphorylation of AKT (C) and PDK1 (D,E). ★P < 0.05, ★★P < 0.01, ★★★P < 0.001. Data are representative of two independent experiments.