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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Nat Neurosci. 2014 May 27;17(6):791–800. doi: 10.1038/nn.3718

Figure 1.

Figure 1

(a) Voxel-wise genetic association analysis. This kind of analysis involves a genome-wide search at each voxel in the brain, after aligning all subjects’ images to a common template. (b) Extending this method to study brain connections, Jahanshad et al.30 described connectome-wide searches. They combined diffusion-based MRI tractography and cortical parcellations to perform GWAS at all connections between cortical regions of interest. Artificial Manhattan plots are illustrated here, with thresholds shown based on a single GWAS. Despite the vast number of tests, promising findings emerged, even after correction, from these whole-connectome genetic screens.