FIGURE 4.
Different behaviors of internalized Salmonella. The majority of Salmonella strains, internalized within an animal cell by the Trigger mechanism mediated by the T3SS-1, are enclosed in a canonical SCV where they can multiply, and form SIF, which allow delivery of nutrients. However, in some cases the bacteria do not have the time (or the capability) to modify the vacuole leading to the fusion of the SCV with phago-lysosome triggering intra-vacuole destruction or autophagy. In other cases, Salmonella damages the SCV membrane triggering vacuole destruction, allowing bacteria to escape into the cytosol, where they can be destroyed, particularly in activated macrophages, or multiply extensively especially in epithelial cells. No data have been obtained for the Zipper mechanism induced by Rck.