Table 3.

Contribution of three RND efflux pumps to antimicrobial resistance of P. aeruginosa PA7.

Strain	Genotype	MIC (μg/ml) of
		CIP	NOR	LVX	MXF	AMK	CHL	IPM
PA7 (PAGU 1498)	Parent	64	128	128	256	32	1024	2
PAGUg1565	PA7 ΔmexXY-oprA	32	64	64	128	1	1024	2
PAGUg1603	PA7 ΔmexAB-oprM	64	128	64	256	32	1024	2
PAGUg1748	PA7 ΔmexEF-oprN	32	64	64	256	32	128	2
PAGUg1641	PA7 ΔmexXY-oprA ΔmexAB-oprM	32	64	32	64	1	1024	2
PAGUg1751	PA7 ΔmexXY-oprA ΔmexEF-oprN	8	16	8	32	1	256	2
PAGUg1753	PA7 ΔmexAB-oprM ΔmexEF-oprN	32	64	32	128	32	16	2
PAGUg1756	PA7 ΔmexXY-oprA ΔmexAB-oprM ΔmexEF-oprN	0.5	0.5	0.5	2	1	4	2
DSM 1128 (PAGU 1504)	Wild type	0.125	0.25	0.25	1	0.5	32	1
PAO1 (PAGU 974)	Wild type	0.125	0.25	0.25	1	0.5	32	1

AMK, amikacin; CHL, chloramphenicol; CIP, ciprofloxacin; IPM, imipenem; LVX, levofloxacin; MXF, moxifloxacin; NOR, norfloxacin.