Table 5.
Pregnancy Outcome in Wistar Rats Treated with ATR during Days 6 to 21 of Gestation (ATR3)
| Dose | Control | 1 mg/kg | 5 mg/kg | 25 mg/kg | 125 mg/kg |
|---|---|---|---|---|---|
| Females | |||||
| Mated | 25 | 25 | 25 | 25 | 25 |
| Pregnant | 20 | 21 | 22 | 25 | 21 |
| No pups delivereda | – | – | – | 1 | 8 |
| Delivering dead pups | – | 1 | 1 | – | – |
| Delivering live pups | 20 | 21 | 21 | 24 | 13 |
| Gestation length | 22.0 ± 0.0 | 22.0 ± 0.4 | 22.2 ± 0.4 | 22.0 ± 0.3 | 22.2 ± 0.4 |
| Implantation sites | 217 | 249 | 258 | 262 | 147 |
| Pups delivered | 201 | 221 | 231 | 243 | 80 |
| Litter size | 10.1 ± 2.9 | 10.5 ± 2.8 | 11.0 ± 2.3 | 10.1 ± 3.3 | 6.2 ± 4.5* |
| Postimplantation loss (%)b | 8.0 | 12.0 | 8.4 | 8.6 | 44.4 |
| Pups alive PND 1 | 200 | 218 | 227 | 240 | 61 |
| Pups alive PND 4 | 200 | 217 | 218 | 239 | 35 |
| Pups alive PND 21 | 184 | 212 | 206 | 225 | 27 |
| Viability index (PNDs 0–4) | 98 | 98 | 92 | 98 | 34 |
| Weaning index (PNDs 4–21) | 94 | 98 | 95 | 95 | 57 |
a
Total intrauterine loss.
b
Postimplantation loss = (no. of implantations − no. of live pups PND 0)/no. of implantations × 100.
*
p < 0.05.