Table 7.
Litter Endpoints for Female Wistar Rats Treated with ATR during Days 2 to 21 of Lactation (ATR4)
| Dose | Control | 1 mg/kg | 5 mg/kg | 25 mg/kg | 125 mg/kg |
|---|---|---|---|---|---|
| Females | |||||
| Pregnant | 31 | 30 | 29 | 33 | 32 |
| Delivering live pups (%) | 30 (97) | 28 (93) | 28 (97) | 32 (97) | 31 (97) |
| Pups delivered | 337 | 301 | 320 | 366 | 333 |
| Meana pups delivered PND0 | 11.2 ± 2.8 | 10.4 ± 3.8 | 11.4 ± 2.9 | 11.4 ± 2.4 | 10.7 ± 2.7 |
| Pups alive PND 0 | 333 | 296 | 319 | 366 | 331 |
| Pups alive PND 21 | 275 | 271 | 275 | 303 | 262 |
| Viability indexb (%) | 96 | 96 | 91 | 93 | 92 |
| Weaning indexc (%) | 84 | 93 | 91 | 89 | 88 |
| Mean live pups per live litters PND1 | 11.3 ± 2.2 | 10.6 ± 3.6 | 11.5 ± 2.7 | 11.4 ± 2.4 | 10.7 ± 2.8 |
| Number of live litters | 29 | 28 | 27 | 32 | 31 |
| Mean live pups per live litters PND21 | 11.0 ± 2.3 | 10.4 ± 3.2 | 11.0 ± 2.4 | 11.2 ± 2.6 | 10.1 ± 2.6 |
| Number of live litters | 25 | 26 | 25 | 27 | 26 |
a
All means presented as means ± standard deviations.
b
Viability index = mean [(number pups alive PND4 / number born alive) × 100].
c
Weaning index = mean [(number pups alive PND21 / number alive PND21) × 100].
*p < 0.05;
**p < 0.01 as determined by covariate analysis (litter size as covariate), covariate adjusted means not shown.