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. 2014 Dec 23;7:102. doi: 10.1186/s13039-014-0102-7

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© Trofimova et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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PO41 tandem repeat is transcribed in chicken lymphoblastoid MDCC-MSB1 cells. FISH with PO41pos (green) and PO41neg (red) probes on chicken MDCC-MSB1 cells. (a, a’) DNA/RNA hybridization revealed transcripts from both strands of PO41 repeat in interphase nuclei. (b, b’) DNA/DNA hybridization (positive control) revealed clusters of PO41 repeat in interphase nuclei. (c, c’) RiboShredder RNase cocktail treatment before DNA/RNA hybridization (negative control) removed all hybridization signals. (d) 3D reconstruction of interphase nucleus with isosurfaces around G-rich transcripts of PO41 repeat (red) and chromatin (blue). DNA was counterstained with DAPI. Scale bars: 5 μm (a-c, a’-c’); 3 μm (d).