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Three-step prenylation processing of proteins. Proteins undergo farnesylation and proteolytic cleavage of aaX residues, followed by carboxymethylation, and then get localized at the plasma membrane. Some proteins, shown here N-Ras, undergo palmitoylation and then localize to plasma membrane, while other proteins, shown here K-Ras, have a polybasic sequence upstream of the “CaaX box” facilitating membrane localization.
