Figure 2.

Structural features of the human kinome. (A) Fractions of human kinase with known structures in the DFG-in, DFG-out, and intermediate conformations. (B) Kinases with DFG-out conformation in the human kinome. Kinases with an experimentally determined structure in the DFG-out conformation are marked with a red circle. Compositions of key amino acids at the (C) gatekeeper and (D) (D – 1) positions. The majority of these amino acids are equally abundant in kinases with a DFG-out crystal structure and those with a DFG-in crystal structure only.