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Enrichment of the consensus DFGmodel models: (A) BRAF, (B) P38α, and (C) S6K1 are S/T-kinases; (D) EPHA3, (E) KIT, and (F) RET are Y-kinases. Blue dotted line represents random selection ligand from a database of ligands and nonbinders. The inserted enrichment plot is the performance of a corresponding DFG-out crystal structure. RET and S6K1 do not have a DFG-out structure for comparison. DFGmodel models perform as well as (e.g., BRAF) or better than the DFG-out crystal structures.
