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. 2014 Dec 26;10(1):63–71. doi: 10.1021/cb500904b

Figure 2.

Figure 2

Examples of PTM-mediated biological processes. (A) Arginine methylation-mediated Smad signaling pathway. (B) p53 interaction with the CBP/p300 complex through methylation and acetylation exchange after DNA damage. P53 is subsequently stabilized and transactivates pro-apoptotic genes. The lower portion of panel B represents a protein-mediated histone crosstalk between methylation and acetylation, leading to chromatin remodeling favorable to transcriptional activation. (C) PTM-mediated cellular trafficking of RAS.