FIG 1.

Analysis of CD8⁺ T-cell populations directed against A2-SL9, B8-EI8, B8-FL8, and B27-KK10. (A) Antigen-specific CD8⁺ T cells were labeled with pHLA-I tetramers and quantified by flow cytometry. Response magnitude is shown as the frequency of tetramer-positive (multimer⁺) events in the total CD8⁺ T-cell population. (B and C) TCRβ diversity was quantified using the relative number of clonotypes (B) and Simpson's diversity index (C). Data are shown for each individual at both the early and late time points.