TABLE 2.
Comparison of T cell reactivity after vaccination and natural infection
| Parameter | Vaccine recipients (NIH) |
Naturally infected donors (Sri Lanka)c |
||
|---|---|---|---|---|
| Monovalentb | Tetravalent | Primary | Secondary | |
| Frequency of responders (%) | 59 | 73 | 22 | 43 |
| Avg no. of epitopes per donor | 6 | 8 | 6 | 11 |
| Avg response per donora | 95 | 235 | 96 | 220 |
| n | 41 | 11 | 55 | 127 |
a
Expressed as IFN-γ SFC/106 PBMC.
b
Expressed as the mean response observed in vaccinees with any of the four monovalent vaccines.
c
Previously reported by Weiskopf et al. (20). Secondary donors are defined as having neutralization titers against at least two of the four serotypes.