TABLE 3.
Epitopes identified in this study
| Protein | Vaccine(s) | HLA | Length (aa)a | Sequence |
|---|---|---|---|---|
| C14-23 | DEN1Δ30 | A*3301 | 10 | FNMLKRARNR |
| C16-24 | DEN1Δ30 | B*0801 | 9 | MLKRERNRV |
| C43-52 | DEN1Δ30, DEN3Δ30,31 | B*0702 | 10 | GPMKLVMAFI |
| C45-53 | DEN4Δ30 | A*0201 | 9 | MVLALITFL |
| C87-96 | DEN1Δ30 | B*4001 | 10 | KEISSMLNIM |
| C104-113 | DENV2/4Δ30 | A*0201 | 10 | ITLLCLIPTV |
| M164-172 | DENV2/4Δ30 | A*0201 | 9 | VTYECPLLV |
| M245-254 | DEN3Δ30,31 | B*3501 | 10 | HPGFTILALF |
| M274-282 | DEN3Δ30,31 | B*3501 | 9 | MLVTPSMTM |
| E329-337 | DEN1Δ30 | B*4001 | 9 | TEVTNPAVL |
| E330-338 | DEN2/4Δ30 | A*3301, A*6801 | 9 | EAKQPATLR |
| E450-459 | DEN1Δ30 | A*0101 | 10 | PTSEIQLTDY |
| E456-464 | DEN1Δ30 | A*0101 | 9 | LTDYGALTL |
| E456-465 | DEN3Δ30,31 | B*3501 | 10 | LPEYGTLGLE |
| E499-507 | DEN3Δ30,31 | B*3501 | 9 | LPWTSGATT |
| E513-521 | DENV2/4Δ30 | A*2301, B*1501 | 9 | IQKETLVTF |
| E513-521 | DEN4Δ30 | A*2402 | 9 | NYKERMVTF |
| E551-560 | DENV2/4Δ30 | A*2301 | 10 | IQMSSGNLLF |
| E578-587 | DEN3Δ30,31 | B*3501 | 10 | MSYAMCTNTF |
| E579-587 | DENV2/4Δ30 | A*2301 | 9 | SYSMCTGKF |
| E716-725 | TV003, DEN3Δ30,31 | B*1501, B*3501 | 10 | MVHQIFGSAY |
| E726-734 | DENV2/4Δ30 | B*5801 | 9 | GAAFSGVSW |
| E738-746 | DEN2/4Δ30 | B*5701, B*5801 | 9 | ILIGVIITW |
| NS1802-810 | TV003 | B*5701 | 9 | HTWTEQYKF |
| NS1880-890 | DEN4Δ30 | B*5301 | 10 | PPASDLKYSW |
| NS1988-996 | DEN4Δ30 | B*4001 | 9 | IEKASLIEV |
| NS11033-1041 | DEN1Δ30 | B*0702 | 9 | RPGYHTQTA |
| NS11042-1051 | DEN1Δ30, DEN3Δ30,31 | B*0702 | 10 | GPWHLGKLEL |
| NS11090-1099 | DEN3Δ30,31 | A*0101 | 10 | RSCTLPPLRY |
| NS11112-1121 | DEN3Δ30,31 | B*3501 | 10 | RPINEKEENM |
| NS2A1143-1151 | DEN3Δ30,31 | B*3501 | 9 | LAILFEEVM |
| NS2A1160-1168 | DEN3Δ30,31 | B*3501 | 9 | MIAGVFFTF |
| NS2A1221-1230 | DEN1Δ30 | B*0801 | 10 | FRRLTSREVL |
| NS2A1244-1252 | DEN4Δ30 | B*5301 | 9 | IPHDLMELI |
| NS2A1265-1273 | DEN1Δ30 | A*0101 | 9 | LTDFQSHQL |
| NS2A1332-1340 | DENV2/4Δ30, DEN4Δ30 | A*0201 | 9 | ALPVYLMTL |
| NS2A1333-1342 | TV003 | B*3501 | 10 | LPVYLMTLMK |
| NS4B1377-1385 | DEN1Δ30 | B*0702 | 9 | GPLVAGGLL |
| NS2B1437-1445 | DENV2/4Δ30, DEN4Δ30 | B*4001, B*4403 | 9 | EETNMITLL |
| NS2B1457-1465 | DEN4Δ30 | B*5301 | 9 | YPLAIPVTM |
| NS2B14631472 | TV003 | A*0301 | 9 | ALWYVWQVK |
| NS31494-1502 | TV003 | A*0201 | 9 | VLDDGIYRI |
| NS31494-1502 | DENV2/4Δ30, DEN4Δ30 | A*0201 | 9 | ALSEGVYRI |
| NS31499-1508 | DEN1Δ30 | B*0801 | 10 | IYRILQRGLL |
| NS31506-1515 | DENV2/4Δ30, DEN4Δ30 | A*0201 | 10 | GLFGKTQVGV |
| NS31519-1527 | DEN2/4Δ30 | B*4403 | 9 | MEGVFHTMW |
| NS31598-1607 | DEN2/4Δ30 | B*4001, B*4403 | 10 | GEIGAVTLDF |
| NS3160-1617 | TV003 | A*0301, A*1101 | 10 | GTSGSPIINK |
| NS31608-1616 | DEN1Δ30, DEN3Δ30,31 | B*0702 | 9 | KPGTSGSPI |
| NS31625-1634 | DEN2/4Δ30, DEN4Δ30, TV003 | A*0301 | 10 | GLYGNGVVTK |
| NS31653-1661 | DEN1Δ30 | B*3501 | 9 | NPEIEDDIF |
| NS31689-1697 | DEN1Δ30 | B*0801 | 9 | AIKRKLRTL |
| NS31700-1709 | TV003 | B*0702, B*3501 | 10 | APTRVVAAEM |
| NS31753-1761 | TV003 | B*3501 | 9 | VPNYNLIVM |
| NS31768-1777 | DEN3Δ30,31 | B*3501 | 10 | DPASIAARGY |
| NS31813-1822 | TV003 | B*4402 | 10 | EERDIPERSW |
| NS31887-1895 | TV003 | A*2601 | 9 | DISEMGANF |
| NS31899-1908 | TV003 | A*0301 | 10 | RVIDPRRCLK |
| NS31899-1907 | DEN1Δ30, DEN3Δ30,31 | B*0702 | 9 | RVIDPRRCL |
| NS31902-1910 | DEN1Δ30, DEN3Δ30,31 | B*0702 | 9 | DPRRCLKPV |
| NS31978-1986 | DEN1Δ30 | B*070, B*3501 | 9 | TPEGIIPSM |
| NS31978-1987 | DEN1Δ30, DEN3Δ30,31 | B*0702, B*3501, B*5301 | 10 | TPEGIIPALF |
| NS32000-2008 | TV003 | A*3301 | 9 | EFRLRGEQR |
| NS32051-2060 | DEN2/4Δ30 | B*4403, B*4402 | 10 | LEENMEVEIW |
| NS32064-2073 | DEN2/4Δ30 | B*4403 | 10 | GERKKLKPRW |
| NS32070-2078 | DEN1Δ30 | B*0702 | 9 | RPRWLDART |
| NS32079-2087 | DEN4Δ30 | A*0101 | 9 | YSDPLALRE |
| NS32093-2102 | DEN1Δ30 | B*0801 | 10 | AGRRSVSGDL |
| NS4A2184-2192 | DEN2/4Δ30 | B*5701 | 9 | IAVASGLLW |
| NS4B2350-2358 | DEN1Δ30 | B*0702 | 9 | NPLTLTAAV |
| NS4B2455-2464 | DEN1Δ30 | B*0702 | 10 | SPGKFWNTTI |
| NS4B2464-2472 | DEN3Δ30,31/Tetra | B*3501 | 9 | IAVSMANIF |
| NS4B2468-2476 | TV003 | B*3501 | 9 | MANIFRGSY |
| NS4B2486-2494 | TV003 | A*0301 | 9 | IMKSVGTGK |
| NS52612-2620 | TV003 | A*0301 | 9 | ATYGWNLVK |
| NS52812-2821 | TV003 | B*5701 | 10 | ASSMVNGVVR |
| NS52830-2838 | DEN1Δ30 | B*0702 | 9 | IPMVTQIAM |
| NS52842-2850 | TV003 | B*3501 | 9 | TPFGQQRVF |
| NS52885-2894 | DEN1Δ30/DEN2/4Δ30, TV003 | B*0702, B*5301 | 10 | TPRMCTREEF |
| NS52899-2908 | DEN2/4Δ30 | B*1501 | 10 | RSNAAIGAVF |
| NS52921-2929 | DEN1Δ30 | B*4001 | 9 | VEDERFWDL |
| NS52956-2964 | TV003 | A*0301 | 9 | KLGEFGRAK |
| NS52962-2970 | TV003 | B*5701 | 9 | KAKGSRAIW |
| NS52977-2986 | TV003 | A*2301 | 10 | RFLEFEALGF |
| NS53083-3091 | DEN1Δ30 | A*6801 | 9 | TVMDVISRR |
| NS53173-3182 | TV003 | A*0301 | 10 | ALLALNDMGK |
| NS53182-3190 | DEN4Δ30, TV003 | B*5701, B*5801 | 9 | KVRKDIPQW |
| NS53218-3227 | DEN1Δ30 | B*4001 | 10 | REIVVPCRNQ |
| NS53246-3254 | Tetravalent | A*2601 | 9 | ETACLGKSY |
| NS53250-3258 | DEN4Δ30 | B*5701 | 9 | LGKSYAQMW |
| NS53254-3262 | DEN2/4Δ30 | B*1501, B*5301 | 9 | YAQMWSLMY |
| NS53290-3299 | DEN1Δ30 | A*2301 | 10 | TWSIHAHHQW |
| NS53291-3299 | TV003 | B*5701 | 9 | WSIHAHHQW |
| NS53327-3338 | DEN3Δ30,31, TV003 | A*0201 | 9 | TTWEDVPYL |
a
aa, amino acids.