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. 2014 Dec 16;89(1):165–180. doi: 10.1128/JVI.01677-14

FIG 6.

FIG 6

NS5BΔ21 directly interacts with RPA and NS3. Panels A through D show surface plasmon resonance analysis of interactions between NS5BΔ21, NS3h, RPA, and T4 gp32. NS5BΔ21 (A) or NS3h (B) was immobilized to the sensor chip, and solutions of either RPA or T4 gp32 were passed over the chip. NS5BΔ21 directly interacted with RPA but not with T4 gp32, whereas NS3h showed no interaction with either RPA or T4 gp32. Panels C and D show NS3h passed over immobilized NS5BΔ21 (C) and NS5BΔ21 passed over immobilized NS3h (D). In both configurations, NS5BΔ21 showed direct interaction with NS3h.