TABLE 2.
Viral sequence variations in relation to proliferative capability of naive-like HCV-specific CD8+ T cellsa
| Outcome of priming | NS31073 sequence | NS31406 sequence |
|---|---|---|
| CINGVCWTV | KLVALGINAV | |
| Proliferation of naive-like T cells | ------V--- (pt. 6) | |
| --T-M----- (pt. 7) | ||
| Lack of proliferation of naive-like T cells | --------- (pt. 14) | ---------- (pt. 14) |
| ---------- (pt. 5) |
a
Autologous bulk viral sequences that correspond to the five naive-like HCV-specific CD8+ T-cell responses from Fig. 4B are shown. For each epitope, the sequence in each line represents the sequence obtained from one patient; hyphens represent sequence homology to the genotype 1a consensus sequence. Numbers in parentheses correspond to patient (pt.) numbers from Table 1.