FIG 5.

Epitope II peptide interferes with E2-CD81 interaction. E2-16Fc was immobilized on a protein A-coated luminescence plate and then incubated with CD81-Luc in the presence of different amounts of epitope II peptide, epitope II mimic peptide, or a non-E2 peptide as a negative control. Luciferase activity representing CD81 binding, shown by the percentage relative to the level of a control CD81-Luc sample in the absence of a peptide competitor, was measured. The data from two independent experiments are presented. A nonlinear regression analysis of these data was performed.