FIG 9.
The frequency of circulating gB-specific CD8+ T cells is inversely correlated with challenge virus shedding in the vaginal tract. Mice were vaccinated, challenged, and divided into three subgroups: those that did not survive (red symbols), those that survived but developed genital disease (black symbols), and those that survived free of genital disease (green symbols). (A and B) Frequencies of Kb/gB496 tetramer-positive CD8+ T cells in blood versus viral titers in genital swabs for groups immunized ivag with HPV-gBsec/gDsec with or without i.m. immunization with gD2t-alum-MPL. (C and D) Graphs show gD-specific IgG antibody titers versus viral titers in genital swabs for groups immunized i.m. with gD2t-alum-MPL with or without ivag immunization with HPV-gBsec/gDsec.