Monocyte ISG12 family expression is elevated in patients above 40,000 copies/ml and associated with viral load. (A) Groupwise comparison of IFI6, IFI27, and IFITM2 gene expression in HIV+ patients below versus above 40,000 (log10 4.6) copies/ml. (B) Spearman ranked correlation of viral load versus monocyte gene expression. Groupwise comparison displays median, interquartile range (box), and range (whiskers) using the Mann-Whitney test (two tailed), with a P value of <0.05 considered significant. Spearman (two tailed) rho and P values are displayed.