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. Author manuscript; available in PMC: 2015 Jan 21.
Published in final edited form as: Biochem J. 2010 Mar 15;427(1):1–17. doi: 10.1042/BJ20091866

Figure 1. β-Catenin-dependent Wnt signalling.

Figure 1

Panels show unstimulated (A), Wnt-stimulated induction of β-catenin/TCF target gene expression (B), and commonly reported mechanisms of feedback inhibition (C). Wnt/β-catenin signalling is inhibited by induction of (1) Dkk1 which sequesters LRP5/6 co-receptors; (2) sFRPs which sequester Wnt ligands; (3) Dapper1 (Dact1) which binds dishevelled proteins; and (4) selective components of the ubiquitin-degradation machinery such as β-TrCP. An animated version of this Figure is available at http://www.BiochemJ.org/bj/427/0001/bj4270001add.htm.