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. Author manuscript; available in PMC: 2015 Jan 21.
Published in final edited form as: Biochem J. 2010 Mar 15;427(1):1–17. doi: 10.1042/BJ20091866

Figure 4. Putative role of Wnt signalling networks in paracrine regulation of titrated adipogenesis.

Figure 4

(A) Paracrine regulation of adipogenesis by Wnt10b. Co-culture experiments demonstrate that Wnt10b-expressing cells do not differentiate, but can also inhibit the adipogenic potential of neighbouring preadipocytes. Co-cultures of preadipocytes expressing either empty vector (EV), Wnt10b or GFP (green fluorescent protein) only were induced to differentiate into adipocytes. Similar results were observed when Wnt10b-expressing preadipocytes were replaced by preadipocytes in which Dact1 was knocked down [98]. Images were generated using Cell-IQ from Chipman Technologies. (B) The paracrine Wnt signalling network mediates cross-talk between preadipocytes and maturing adipocytes. This network is also nutritionally regulated and may regulate titrated adipocyte recruitment in vivo [98].