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. Author manuscript; available in PMC: 2015 Jan 21.
Published in final edited form as: Biochem J. 2010 Mar 15;427(1):1–17. doi: 10.1042/BJ20091866

Figure 5. Adipose tissue expansion during the development of obesity and diabetes is accompanied by dynamic alterations in Wnt/β-catenin signalling components.

Figure 5

As adipose tissue expands, activators of Wnt/β-catenin signalling are decreased while inhibitors increase. However, this reciprocal regulation appears to be uncoupled in dysfunctional obese insulin-resistant adipose tissue, probably due to increased pro-inflammatory cytokine activity. BMI, body mass index; HFD, high-fat diet.