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. 2014 Dec 1;9(2):869–874. doi: 10.3892/ol.2014.2753

Figure 2.

Figure 2

(A) The seed sequences of miR-133a against the wild-type or mutant 3′-UTR of FSCN1. (B) Luciferase reporter assay identified that co-transfection of SW480 cells with miR-133a mimics and wild-type FSCN1 3′-UTR caused a significant decrease in luciferase activity, whereas co-transfection with mutant FSCN1 3′-UTR and miR-133a mimics showed no significant difference compared with the control group. Control, cells co-transfected with blank vector and wild-type SP1R1 3′-UTR or mutant FSCN1 3′-UTR. *P<0.01, vs. control. FSCN1, Fascin1; UTR, untranslated region; miR, microRNA; NC, negative control.