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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2014 Sep 18;7(6):1205–1213. doi: 10.1161/CIRCEP.113.001666

Figure 1.

Figure 1

CaMKIIδC myocytes are susceptible to EADs and SCR. A. Representative Tg cell transitioning to EADs during Iso challenge. B. EAD frequency (% of all cycles, left) and incidence (right) was increased in Tg compared to WT cells during Iso. Neither group exhibited EADs in Normal Tyrode’s (NT). C. Left: representative Ca2+ recordings during pause-induced SR Ca2+ release experiments. Right: summary data for SCR incidence (fraction of cells with 1 or more SCR events), SCR frequency (events/cell), and SR Ca2+ content at baseline, during Iso, and in elevated extracellular Ca2+ (2 mM, SR Ca2+ content only). Cell numbers are inset to each bar. **p < 0.01, *p < 0.05, † p = 0.06. Data are mean±SEM.