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SR Ca2+ release is required for EAD initiation. A. Caffeine (10 mM) eliminates EADs by depleting the SR Ca2+ store. B. EADs from the solid boxed region in panel A. C. AP morphologies from the NT (solid line), Iso (dashed line), and post-caffeine (dotted line) records. Iso and post-caffeine APs are boxed in (A).
