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. 2015 Jan 13;9:1. doi: 10.1186/s12918-014-0137-8

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© Ye et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Changes of reactions involving NADPH at different ARA levels. (Different colors represent different changes on NADPH flux. Flux obviously changed reactions are listed. R2: D-glucose 6-phosphate + NADP ⬄ 6-phospho-D-glucono-1,5-lactone + NADPH + H, R3: 6-phospho-D-gluconate + NADP - > D-ribulose 5-phosphate + CO2 + NADPH + H, R4: (S)-malate + NADP - > pyruvate + CO2 + NADPH, R5: L-glutamate 5-semialdehyde + NAD P+ H2O - > L-glutamate + NADPH + H, R6: 1-pyrroline-5-carboxylate + NADPH + H ⬄ L-proline + NADP, R16: Nitrite + 3 NADPH + 5 H - > Ammonia + 3 NADP + 2 H2O, R51: N-acetyl-L-glutamyl 5-phosphate + NADPH + H ⬄ N-acetyl-L-glutamate 5-semialdehyde + NADP + Phosphate, R53: (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H ⬄ (R)-mevalonate + CoA + 2 NADP).