Table 4.

Diagnostic value of methylglyoxal, C-reactive protein, procalcitonin, interleukin-6, and soluble CD14 subtype for identification of patients with sepsis

Parameter	AUC (S/T0 vs. P/T2)	Cutoff	Sensitivity	1-Specificity	Results of pairwise comparisons
MG, nM	0.993	281.1	0.912	0.000
CRP, mg/L	0.791	152.8	0.667	0.148	<0.001***
PCT, μg/L	0.844	1.46	0.772	0.222	0.002**
IL-6, pg/mL	0.898	401.0	0.737	0.037	0.007**
sCD14-ST, pg/mL	0.832	825	0.912	0.333	<0.001***

Receiver operating characteristic (ROC) analysis was performed with suitable parameters in order to create cutoff values to determine the diagnostic value of each parameter with regard to the diagnosis of sepsis (S/T0 versus P/T2). Area under the curve (AUC) comparisons of the related ROC curves refer to pairwise comparisons of each parameter with MG. With regard to symbolism and higher orders of significance: **P <0.01; ***P <0.001. CRP, C-reactive protein; IL-6, interleukin-6; MG, methylglyoxal; ns, not statistically significant; PCT, procalcitonin; sCD14-ST, soluble CD14 subtype.