Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Dec 5;2(1):43–55. doi: 10.1002/acn3.152

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

(A) Heat map using three data sets (healthy controls, multiple sclerosis [MS] before natalizumab, MS during natalizumab). In order to cluster the data we applied complete linkage hierarchical clustering of the miRNA patterns using the Euclidian distance as distance measure. To focus on the most informative miRNAs, the 100 with highest data variance have been selected. Nat = natalizumab treatment. B) Venn diagrams showing the overlapping miRNA targets for comparison of untreated MS subjects versus healthy controls (HC) and MS patients pre- versus postnatalizumab treatment. The left diagram shows the overlap of miRNAs downregulated in untreated MS with natalizumab-regulated miRNAs (Up by Nat: upregulated in natalizumab treatment; Down by Nat: downregulated in natalizumab treatment). The right diagram shows the overlap of miRNAs upregulated in untreated MS patients versus healthy controls (HC) with natalizumab-regulated miRNAs.