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. Author manuscript; available in PMC: 2015 Jan 21.
Published in final edited form as: Curr Opin Genet Dev. 2011 Apr 30;21(4):407–413. doi: 10.1016/j.gde.2011.04.005

Figure 2. TLS structure and recruitment to the dynein motor.

Figure 2

The TLS consists of an extended helical region in A' form, with two subdomains in which the major groove (darkest shading) are 90° out of register with one another. Egl binds the TLS, presumably recognizing the offset A' helices, as well as Bic-D. Egl activates Bic-D, and Bic-D and Egl contact components of the dynein motor complex, allowing transport along microtubules.