Table 3.
Random effect models for difference in psychological and quality-of-life outcomes between FH and PS groups over time
| Model and variable | Coef. | Sth. Err | P>|z| | 95% CI |
|---|---|---|---|---|
| Random effects model for HADS | ||||
| Group | −0.472 | 0.344 | 0.169 | −1.146 to 0.201 |
| Occasion 2 | −0.473 | 0.484 | 0.328 | −1.422 to 0.475 |
| Occasion 3 | −0.881 | 0.740 | 0.234 | −2.331 to 0.570 |
| Group#Occasion | ||||
| 1 2 | −0.473 | 0.484 | 0.328 | −1.422 to 0.475 |
| 1 3 | −0.881 | 0.740 | 0.234 | −2.331 to 0.570 |
| Sex | −1.292 | 0.360 | <0.0005 | −1.997 to −0.587 |
| FH | 0.651 | 0.506 | 0.198 | −0.341 to 1.643 |
| Age | −0.035 | 0.011 | 0.002 | −0.057 to −0.013 |
| Income | −0.544 | 0.128 | <0.0005 | −0.795 to −0.293 |
| Marital status | 0.556 | 0.460 | 0.227 | −0.345 to 1.458 |
| HADS depression | ||||
| Group | −0.220 | 0.166 | 0.184 | −0.545 to 0.105 |
| Occasion 2 | 0.114 | 0.309 | 0.711 | −0.491 to 0.719 |
| Occasion 3 | −0.141 | 0.392 | 0.718 | −0.910 to 0.627 |
| Group#Occasion | ||||
| 1 2 | −0.330 | 0.323 | 0.307 | −0.962 to 0.303 |
| 1 3 | −0.108 | 0.405 | 0.790 | −0.901 to 0.685 |
| Sex | −0.166 | 0.173 | 0.337 | −0.505 to 0.173 |
| FH | 0.345 | 0.253 | 0.173 | −0.151 to 0.840 |
| Age | −0.002 | 0.005 | 0.710 | −0.012 to 0.008 |
| Income | −0.254 | 0.064 | <0.0005 | −0.379 to −0.129 |
| Marital status | 0.267 | 0.223 | 0.232 | −0.171 to 0.705 |
| HADS anxiety | ||||
| Group | −0.252 | 0.228 | 0.270 | −0.699 to 0.196 |
| Occasion 2 | −0.584 | 0.325 | 0.072 | −1.220 to 0.0526 |
| Occasion 3 | −0.738 | 0.434 | 0.089 | −1.589 to 0.113 |
| Group#Occasion | ||||
| 1 2 | −0.126 | 0.350 | 0.719 | −0.811 to 0.560 |
| 1 3 | −0.315 | 0.457 | 0.491 | −1.210 to 0.580 |
| Sex | −1.129 | 0.231 | <0.0005 | −1.582 to −0.676 |
| FH | 0.305 | 0.334 | 0.361 | −0.349 to 0.959 |
| Age | −0.033 | 0.008 | <0.0005 | −0.048 to −0.018 |
| Income | −0.288 | 0.081 | <0.0005 | −0.447 to −0.130 |
| Marital status | 0.285 | 0.293 | 0.331 | −0.289 to 0.860 |
| Random effects model for SF12 | ||||
| SF12-MCS | ||||
| Group | 0.373 | 0.356 | 0.295 | −0.325 to 1.071 |
| Occasion 2 | 0.493 | 0.734 | 0.502 | −0.945 to 1.932 |
| Occasion 3 | −0.289 | 0.690 | 0.676 | −1.641 to 1.064 |
| Group#Occasion | ||||
| 1 2 | −0.647 | 0.784 | 0.409 | −2.183 to 0.889 |
| 1 3 | −0.058 | 0.734 | 0.937 | −1.496 to 1.381 |
| Sex | 0.480 | 0.325 | 0.141 | −0.158 to 1.117 |
| FH | −1.007 | 0.531 | 0.058 | −2.047 to 0.033 |
| Age | 0.081 | 0.011 | 0.000 | 0.059 to 0.102 |
| Income | 0.084 | 0.120 | 0.481 | −0.151 to 0.319 |
| Marital status | 0.994 | 0.453 | 0.028 | 0.106 to 1.882 |
| SF12-PCS | ||||
| Group | 0.193 | 0.330 | 0.558 | −0.453 to 0.839 |
| Occasion 2 | 0.634 | 0.625 | 0.311 | −0.592 to 1.859 |
| Occasion 3 | 0.619 | 0.606 | 0.307 | −0.568 to 1.807 |
| Group#Occasion | ||||
| 1 2 | −0.797 | 0.669 | 0.233 | −2.108 to 0.514 |
| 1 3 | −0.877 | 0.651 | 0.178 | −2.154 to 0.399 |
| Sex | 1.656 | 0.301 | <0.0005 | 1.066 to 2.246 |
| FH | 0.344 | 0.465 | 0.460 | −0.568 to 1.256 |
| Age | −0.092 | 0.011 | <0.0005 | −0.115 to −0.070 |
| Income | 0.361 | 0.113 | 0.001 | 0.139 to 0.583 |
| Marital status | 0.080 | 0.415 | 0.846 | −0.733 to 0.894 |
The group-by-time interaction was not statistically significant for any of the models. Reference categories for the following variables is denoted by*: *Group 0 = FH (family history); Group 1 = PS (population screening); *Occasion 1 = baseline; Occasion 2 = time point 2 (7 days post test result); Occasion 3 = time point 3 (three months post test result); Sex 0 = female; Sex 1 = male; *FH 0 = low risk; FH 1 = high risk. *Marital Status 0 = live alone, ie, single/divorced/widowed; marital Status 1 = live with partner, ie, married/cohabiting. Income as “continuous variable,” but measured in £10 000 increments. Age in years (continuous variable). Coef = coefficient; Err = error; FH = family history; Group#Occasion = group-by-time interaction effect; HADS = Hospital Anxiety and Depression Scale; PS = population screening; SF12 PCS = SF12 quality-of-life physical component scale; SF12 MCS = SF12 quality-of-life mental component scale; QoL = quality-of-life; Std = standard.