Effect of 6 weeks of voluntary wheel running on IL-6 and IL-10 response to acute tail shock stress in non-obese white adipose tissue (WAT). Sedentary (SED □) and exercised (RUN ■) rats were exposed to 0 (control condition) or 100 acute, inescapable tail shocks (IS), immediately sacrificed and subcutaneous, intraperitoneal and visceral WAT collected. Shown is the mean (+ SEM) concentration of (A) interleukin (IL)-6 (IL-6) **P < 0.01, ***P < 0.0001 (0IS SED vs. 100IS SED, 0IS RUN vs. 100IS RUN), ###P < 0.0001 (100IS SED vs. 100IS RUN). (B) IL-10, ***P < 0.0001 (0IS RUN vs. 100IS RUN), ***P < 0.0001 (Subcutaneous 0IS SED vs. Subcutaneous100IS SED), ###P < 0.0001 (100IS SED vs. 100IS RUN); three factor ANOVA with Bonferroni post hoc analysis.