Table 1.
Clinical data
| Patient | Gender | Onset age (years) | Onset | Duration (years) | Clinical course | Pain |
|---|---|---|---|---|---|---|
| TISN | ||||||
| 1 | F | 41 | Unilateral paroxysmal pain | 20 | After 15 years, bilateral ongoing pain and mild sensory deficits. | YES |
| 2 | F | 55 | Bilateral sensory deficit | 16 | Stable | NO |
| 3 | M | 57 | Unilateral paroxysmal and ongoing pain | 13 | Slowly developing bilateral sensory deficit and ongoing pain. | YES |
| 4 | M | 63 | Unilateral paroxysmal pain | 8 | Slowly developing bilateral sensory deficit and ongoing pain. | YES |
| 5 | F | 23 | Unilateral sensory deficit | 8 | After 5 years bilateral sensory deficit. | NO |
| 6 | F | 77 | Bilateral paroxysmal and ongoing pain | 7 | Slowly developing bilateral sensory deficit and ongoing pain. | YES |
| 7 | M | 55 | Bilateral sensory deficit | 6 | After 6 years bilateral sensory deficit. | NO |
| 8 | F | 63 | Unilateral paroxysmal and ongoing pain | 6 | After 5 years bilateral sensory deficit. | YES |
| FOSMN | ||||||
| 9 | M | 49 | Unilateral ongoing pain | 15† | Pain and sensory deficits progressively became bilateral. Motor disturbances began after 6 years. Death 15 years after onset of sensory symptoms. | YES |
| 10 | M | 50 | Bilateral ongoing pain | 13 | Sensory deficits progressively developed bilaterally. Motor disturbances began after 4 years. In evolution. | YES |
| 11 | F | 58 | Bilateral ongoing pain | 8 | Sensory deficits progressively developed bilaterally. Motor disturbances began after 2 years. In evolution. | YES |
| 12 | F | 53 | Bilateral sensory deficit | 8 | Motor disturbances began after 6 years. In evolution. | NO |
| 13 | F | 56 | Unilateral ongoing pain | 6† | Pain and sensory deficits progressively became bilateral. Motor disturbances began after 4 years. Death 6 years after onset of sensory symptoms. | YES |
TISN: Trigeminal isolated sensory neuropathy. FOSMN: Facial onset sensory-motor neuronopathy. †deceased.