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. 2014 Dec 11;18(6):682. doi: 10.1186/s13054-014-0682-y

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© Granfeldt et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Pulmonary function. Infusion of adenosine, lidocaine and magnesium (ALM) improved pulmonary function, indicated by a lower mean pulmonary arterial pressure, a lower alveolar–arterial oxygen difference, a lower wet/dry ratio and a higher PaO₂/FiO₂ ratio. (A) Mean pulmonary arterial pressure. (B) Alveolar–arterial oxygen difference. (C) PaO₂/FiO₂ ratio. (D) Pulmonary wet/dry ratio. *Significant difference at the end of the study. #Significantly different change over time between groups. ¥Significant difference before/after cessation ALM infusion. Mean pulmonary arterial pressure and PAO₂–PaO₂ difference are presented as median (95% confidence interval), while the PaO₂/FiO₂ ratio is presented as mean (95% confidence interval). Pulmonary wet/dry ratio presented as mean and individual values. FiO₂, inspired fraction of oxygen; LPS, lipopolysaccharide; PaO₂, arterial partial pressure of oxygen; PAO₂, alveolar partial pressure of oxygen.