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. 2014 Dec 11;18(6):682. doi: 10.1186/s13054-014-0682-y

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© Granfeldt et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Renal function. A temporary impairment of renal function was observed during infusion of adenosine, lidocaine and magnesium (ALM), demonstrated by a decrease in urine output and creatinine clearance and an increase in plasma creatinine levels; however, this reversed after infusion was turned off. (A) Urine output during the study, measured hourly. (B) Plasma creatinine levels. (C) Creatinine clearance. (D) Urinary neutrophil gelatinase-associated lipocalin (NGAL)/creatinine ratio. *Significant difference at the end of the study. #Significantly different change over time between groups. †Significantly different development over time during infusion of ALM. ¥Significant difference before/after cessation ALM infusion. Data presented as median (95% confidence interval), except for creatinine clearance that is presented as mean (95% confidence interval). LPS, lipopolysaccharide.