Table 2.
Plasma cytokines and renal function
| Baseline | 30 minutes | 60 minutes | 90 minutes | 120 minutes | 150 minutes | 180 minutes | 210 minutes | 240 minutes | 300 minutes | |
|---|---|---|---|---|---|---|---|---|---|---|
| Interleukin-6 (pg/ml) | ||||||||||
| Control | 6 (4 to 10) | 5 (3 to 8) | 4 (2 to 6) | 32 (19 to 53) | 107 (65 to 178) | 168 (102 to 279) | 221 (133 to 366) | 174 (105 to 289) | 83 (50 to 138) | |
| ALM | 4 (3 to 7) | 4 (3 to 7) | 6 (4 to 10) | 45 (27 to 75) | 177 (107 to 293) | 272 (164 to 451) | 339 (204 to 561) | 266 (161 to 441) | 90 (54 to 149) | |
| Interleukin-10 (pg/ml) | ||||||||||
| Control | 5 (3 to 8) | 10 (6 to 17) | 327 (201 to 532) | 391 (240 to 636) | 215 (132 to 350) | 213 (131 to 347) | 392 (241 to 638) | 419 (257 to 681) | 315 (194 to 512) | |
| ALM | 6 (4 to 11) | 14 (8 to 22) | 303 (186 to 492) | 463 (285 to 754) | 341 (209 to 554) | 297 (182 to 483) | 347 (213 to 564) | 354 (218 to 576) | 383 (235 to 623) | |
| Urinary protein/creatinine ratio (μg/μmol) | ||||||||||
| Control | 7.5 (5.5 to 10.3) | 7.6 (5.5 to 10.4) | 9.4 (6.8 to 12.9) | 10.1 (7.4 to 13.9) | 10.2 (7.5 to 14.1) | 11.1 (8.1 to 15.2) | ||||
| ALMa | 9.1 (6.6 to 12.5) | 8.4 (6.1 to 11.5) | 14.1 (10.1 to 19.3) | 24.3 (17.7 to 33.4) | 19.5 (14.2 to 26.7) | 14.7 (10.7 to 20.2) | ||||
| Urinary NAGase/creatinine ratio (U/mmol) | ||||||||||
| Control | 2.2 (1.5 to 3.3) | 2.0 (1.3 to 3.0) | 2.2 (1.5 to 3.3) | 1.8 (1.2 to 2.8) | 1.8 (1.2 to 2.8) | 2.2 (1.4 to 3.3) | ||||
| ALMb | 2.1 (1.4 to 3.2) | 2.1 (1.4 to 3.2) | 3.0 (2.0 to 4.5) | 6.3 (4.2 to 9.5) | 6.5 (4.3 to 9.7) | 3.0c (2.0 to 4.5) |
Data presented as median (95% confidence interval). ALM, adenosine, lidocaine and magnesium; NAGase, N-acetyl-β-d-glucosaminidase. aSignificantly different mean/median level. bSignificantly different change over time between groups. cSignificant difference before/after cessation ALM infusion.