Table 4.
Systemic arterial gas and metabolic variables
| Baseline | 30 minutes | 60 minutes | 90 minutes | 120 minutes | 150 minutes | 180 minutes | 210 minutes | 240 minutes | 270 minutes | 300 minutes | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Arterial pH | |||||||||||
| Control | 7.48 (7.47 to 7.49) | 7.48 (7.47 to 7.50) | 7.44 (7.43 to 7.46) | 7.44 (7.42 to 7.45) | 7.44 (7.42 to 7.45) | 7.42 (7.40 to 7.43) | 7.41 (7.40 to 7.43) | 7.41 (7.39 to 7.42) | 7.41 (7.40 to 7.43) | 7.41 (7.40 to 7.42) | 7.41 (7.39 to 7.42) |
| ALM | 7.48 (7.47 to 7.50) | 7.48 (7.46 to 7.49) | 7.45 (7.44 to 7.46) | 7.44 (7.42 to 7.45) | 7.41 (7.40 to 7.43) | 7.41 (7.40 to 7.43) | 7.40 (7.39 to 7.42) | 7.40 (7.39 to 7.42) | 7.40 (7.38 to 7.42) | 7.40 (7.38 to 7.41) | 7.40 (7.39 to 7.41) |
| PaO2 (mmHg) | |||||||||||
| Control | 182 (161 to 205) | 118 (105 to 135) | 154 (136 to 173) | 157 (139 to 177) | 144 (127 to 162) | 117 (103 to 132) | 111 (98 to 125) | 110 (98 to 124) | 127 (112 to 143) | 126 (111 to 142) | 115 (102 to 130) |
| ALMa | 184 (163 to 207) | 173 (154 to 196) | 174 (154 to 197) | 169 (150 to 191) | 168 (148 to 189) | 170 (150 to 191) | 167 (148 to 188) | 163 (144 to 184) | 150 (133 to 169) | 151 (134 to 171) | 147b (130 to 166) |
| PaCO2 (mmHg) | |||||||||||
| Control | 43 (42 to 44) | 41 (40 to 42) | 44 (42 to 45) | 44 (42 to 45) | 44 (43 to 45) | 44 (43 to 46) | 45 (44 to 46) | 45 (44 to 46) | 44 (43 to 45) | 43 (42 to 44) | 44 (43 to 45) |
| ALM | 43 (41 to 44) | 41 (40 to 42) | 42 (41 to 44) | 42 (41 to 44) | 44 (43 to 35) | 44 (42 to 45) | 44 (43 to 45) | 43 (42 to 44) | 44 (42 to 45) | 45 (44 to 46) | 45 (44 to 46) |
| ETCO2 (mmHg) | |||||||||||
| Control | 43 (42 to 45) | 42 (41 to 43) | 45 (44 to 47) | 45 (44 to 46) | 44 (43 to 45) | 43 (42 to 45) | 42 (40 to 43) | 41 (39 to 42) | 40 v(39 to 41) | 40 (39 to 41) | 40 (39 to 41) |
| ALMc | 45 (44 to 46) | 42 (41 to 44) | 45 (44 to 46) | 45 (43 to 46) | 45 (44 to 47) | 44 (43 to 46) | 45 (44 to 46) | 44 (42 to 45) | 44 (43 to 45) | 44 (43 to 45) | 44b (42 to 45) |
| HCO3 – (mmol/l) | |||||||||||
| Control | 31.4 (30.6 to 32.2) | 30.5 (29.7 to 31.3) | 29.1 (28.3 to 29.9) | 28.7 (27.9 to 29.4) | 28.7 (27.9 to 29.4) | 27.8 (27.1 to 28.6) | 27.6 (26.8 to 28.4) | 27.1 (26.3 to 27.9) | 26.9 (26.1 to 27.7) | 26.6 (25.8 to 27.4) | 26.8 (26.0 to 27.6) |
| ALM | 31.4 (30.7 to 32.2) | 30.3 (29.5 to 31.0) | 29.0 (28.2 to 29.8) | 28.1 (27.3 to 28.8) | 27.4 (26.6 to 28.1) | 27.0 (26.2 to 27.7) | 26.6 (25.8 to 27.4) | 26.5 (25.7 to 27.3) | 26.1 (25.3 to 26.9) | 26.4 (25.6 to 27.1) | 26.6 (25.8 to 27.4) |
| Lactate (mmol/l) | |||||||||||
| Control | 0.8 (0.6 to 0.9) | 0.8 (0.6 to 1.0) | 1.1 (0.9 to 1.2) | 1.1 (0.9 to 1.2) | 1.2 (1.0 to 1.3) | 1.2 (1.1 to 1.4) | 1.3 (1.1 to 1.4) | 1.3 (1.2 to 1.5) | 1.3 (1.2 to 1.5) | 1.2 (1.1 to 1.4) | 1.1 (0.9 to 1.2) |
| ALMc | 0.7 (0.6 to 0.9) | 1.0 (0.8 to 1.1) | 1.2 (1.0 to 1.3) | 1.2 (1.0 to 1.4) | 1.2 (1.0 to 1.4) | 1.2 (1.0 to 1.3) | 1.2 (1.0 to 1.3) | 1.1 (1.0 to 1.3) | 1.1 (0.9 to 1.3) | 1.0 (0.8 to 1.1) | 0.8b (0.7 to 1.0) |
Data presented as median (95% confidence interval), except for pH, lactate, and ETCO2 which are presented as mean (95% confidence interval). ALM, adenosine, lidocaine and magnesium; ETCO2, end-tidal carbon dioxide; PaCO2, arterial partial pressure of carbon dioxide; PaO2, arterial partial pressure of oxygen. aSignificantly different mean/median level between groups. bSignificant difference at the end of the study. cSignificantly different change over time between groups.