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. 2014 Dec 15;14:488. doi: 10.1186/1472-6882-14-488

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© Li et al.; licensee BioMed Central. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Outline of tumor models and treatment protocols used in this study. (Upper panel) treatment protocols and administration routes for different drugs. KSY: 1000 mg/kg/day, p.o.; OK-432: 4 mg/kg per injection, i.p.; Lipo-Dox: 1.5 mg/kg per injection, i.v.. (Bottom panel) tumor mouse models used in this study. In the C3-B model, C3H/HeN mice were injected with a syngeneic bladder cancer cell line MBT-2. In the Nu-B model, BALB/cAnN-Foxn1nu/Cr1Nar1 mice were inoculated with MBT-2 cells. In the B6-L model, C57BL/6 mice were injected with a syngeneic lung cancer cell line LLC-1. The detailed experimental procedures are described in the “Methods”.