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. 2014 Dec 10;12:340. doi: 10.1186/s12967-014-0340-9

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© Ménard et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Dose- and time-dependent effects of LCI699 on ACTH-stimulated aldosterone, cortisol and precursors (human study, multiple-dose phase). Mean plasma concentrations of (A) aldosterone, (B) cortisol, (C) the aldosterone precursor 11-deoxycorticosterone (11-DOC), and (D) the cortisol precursor 11-deoxycortisol, at 0, 30 and 60 min after adrenocorticotropic hormone (ACTH) administration at baseline (Day –2) and on Days 6 and 13 of once-daily treatment with LCI699 (0.5, 1 or 3 mg), eplerenone (100 mg) or placebo in healthy human volunteers. Values are means. Number of evaluable subjects for LCI699 0.5, 1, 3 mg, eplerenone and placebo were (Day -2 and 6) n = 12, 12, 12, 10 and 9 respectively, and (Day 13) n = 12, 12, 9, 8 and 8 respectively. *P < 0.05, ^† P < 0.01, ^‡ P < 0.001 vs placebo.