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. Author manuscript; available in PMC: 2015 Mar 25.
Published in final edited form as: Nature. 2014 Jul 13;513(7519):559–563. doi: 10.1038/nature13490

Extended Data Figure 8. A subset of TAM markers can be induced by lactic acid and require HIF1α.

Extended Data Figure 8

Expression analysis by qPCR of MHC II, Mrc1 and Cd11c mRNA from the following cell types: bone-marrow-derived macrophages stimulated with 25 mM lactic acid (a); TAMs from LLC tumours resected from mice with macrophages that are either wild-type (WT; C57BL/6J) or in which Hif1a has been deleted (b). Where indicated, the relative expression histograms represent three biological replicates displayed as mean ± s.e.m.