. 2014 Dec 15;14:950. doi: 10.1186/1471-2407-14-950

Table 1.

Characteristics of studies included in the meta-analysis

First author	Year	Country	Ethnicity	Cancer type	Gene type	Source of controls	Cases	Controls		Case		Control		HWE
									MM	MW	WW	MM	MW	WW
Clifford	2001	UK	Caucasian	Renal	C1772T	PB	48	143	42	6	0	110	27	6	0.02
					G1790A	PB	48	144	47	1	0	140	4	0	0.87
Tanimoto	2003	Japan	Asian	HNSCC	C1772T	PB	55	110	45	10	0	98	12	0	0.55
					G1790A	PB	55	110	51	4	0	101	9	0	0.65
Kuwai	2004	Japan	Asian	Colorectal	C1772T	PB	100	100	100	0	0	89	11	0	0.56
Ollerenshaw	2004	UK	Caucasian	Renal	C1772T	PB	160	162	16	54	90	1	90	71	0.001
					G1790A	PB	146	288	65	67	14	239	39	10	0.001
Ling	2005	China	Asian	Esophageal	C1772T	HB	95	104	84	11	0	93	11	0	0.57
Chau	2005	USA	Caucasian	Prostate	C1772T	PB	196	196	161	29	6	179	14	3	0.002
Fransen	2006	Sweden	Caucasian	Colorectal	C1772T	PB	198	258	167	28	3	213	43	2	0.92
Fransen	2006	Sweden	Caucasian	Colorectal	G1790A	PB	198	256	189	9	0	247	9	0	0.77
Konac	2007	Turkey	Caucasian	Cervical	C1772T	HB	32	107	10	14	8	68	37	2	0.23
					G1790A	HB	32	107	32	0	0	107	0	0	0.99
			Caucasian	Ovarian	C1772T	HB	49	107	34	14	1	68	37	2	0.23
					G1790A	HB	49	107	47	2	0	107	0	0	0.99
			Caucasian	Endometrial	C1772T	HB	21	107	4	12	5	68	37	2	0.23
					G1790A	HB	21	107	21	0	0	107	0	0	0.99
Li	2007	USA	mixed	Prostate	C1772T	PB	1041	1234	818	209	14	995	221	18	0.16
					G1790A	PB	1066	1264	1053	13	0	1247	17	0	0.81
Orr-Urtreger	2007	Israel	Caucasian	Prostate	C1772T	PB	402	300	287	99	16	217	80	3	0.14
					G1790A	PB	200	300	198	2	0	298	2	0	0.95
Apaydin	2008	Turkey	Caucasian	Breast	C1772T	PB	102	102	79	21	2	68	29	5	0.42
					G1790A	PB	102	102	102	0	0	98	4	0	0.84
Lee	2008	Korea	Asian	Breast	C1772T	PB	1332	1369	1207	119	6	1245	123	1	0.25
Kim	2008	Korea	Asian	Breast	C1772T	HB	90	102	81	8	1	93	9	0	0.64
					G1790A	HB	90	102	87	3	0	94	7	1	0.06
Nadaoka	2008	Japan	Asian	Bladder	C1772T	HB	219	461	197	21	1	419	42	0	0.35
					G1790A	HB	219	461	204	13	2	421	40^*	-	0.46
Jacobs	2008	USA	mixed	Prostate	C1772T	HB	1420	1450	1156	252	12	1138	284	28	0.04
Horree	2008	Netherland	Caucasian	Endometrial	C1772T	PB	58	559	50	5	3	463	84	12	0.01
Naidu	2009	Malaysia	Asian	Breast	C1772T	PB	410	275	294	100	16	222	50	3	0.92
					G1790A	PB	410	275	332	72	6	232	41	2	0.90
Chen	2009	Taiwan	Asian	Oral	C1772T	PB	174	347	163	10	1	334	13	0	0.72
					G1790A	PB	174	347	153	20	1	333	14	0	0.70
Konac	2009	Turkey	Caucasian	Lung	C1772T	PB	141	156	110	31	0	111	43	2	0.34
					G1790A	PB	141	156	141	1	0	154	2	0	0.94
Morris	2009	UK	Caucasian	Renal	C1772T	PB	332	313	290	39	3	262	46	5	0.08
					G1790A	PB	325	309	313	10	2	294	15	0	0.66
Foley	2009	Ireland	Caucasian	Prostate	C1772T	PB	95	188	65	30	0	175	13	0	0.62
Li	2009	China	Asian	Gastric	C1772T	HB	87	106	83	4	0	93	13	0	0.50
					G1790A	HB	87	106	74	13	0	100	6	0	0.76
Munoz-
Guerra	2009	Spain	Caucasian	Oral	C1772T	PB	70	148	57	6	7	113	27	8	<0.01
					G1790A	PB	64	139	40	21	3	130	9	0	0.69
Kim	2010	Korea	Asian	Cervical	C1772T	HB	199	214	177	22	0	187	27	0	0.32
					G1790A	HB	199	213	187	12	0	200	12	1	0.10
Shieh	2010	Taiwan	Asian	Oral	C1772T	HB	305	96	282	23	0	89	7	0	0.71
					G1790A	HB	305	96	281	24	0	89	7	0	0.71
Knechtal	2010	Austria	Caucasian	Colorectal	C1772T	PB	368	2156	291	77^**	-	1773	383^*	-	>0.05
					G1790A	PB	367	2156	356	11^*	-	2080	76^*	-	>0.05
Hsiao	2010	Taiwan	Asian	Hepatocellul-ar	C1772T	HB	102	347	94	8	0	334	13	0	0.72
					G1790A	HB	102	347	87	15	0	333	14	0	0.70
Xu	2011	China	Asian	Glioma	C1772T	HB	150	150	121	27	2	135	14	1	0.35
Putra	2011	Japan	Asian	Lung	C1772T	PB	83	110	74	9	0	98	12	0	0.55
					G1790A	PB	83	110	72	9	2	101	9	0	0.65
Kang	2011	Korea	Asian	Colorectal	C1772T	PB	50	50	46	4^**	-	38	12^**	-	<0.01
Wang	2011	China	Asian	Pancreatic	C1772T	HB	263	271	209	54	0	242	29	0	0.35
					G1790A	HB	263	271	198	65	0	249	22	0	0.49
Zagouri	2012	Greece	Caucasian	Breast	C1772T	HB	113	124	98	15	0	107	17	0	0.41
Kuo	2012	Taiwan	Asian	Lung	C1772T	HB	285	300	153	94	38	216	73	11	0.13
					G1790A	HB	285	300	150	94	41	215	74	11	0.15
Qin	2012	China	Asian	Renal	C1772T	HB	620	623	572	46	2	578	43	2	0.22
					G1790A	HB	620	623	575	45	0	584	39	0	0.42
Li	2012	China	Asian	Prostate	C1772T	HB	662	716	612	48	2	659	57	0	0.27
					G1790A	HB	662	716	614	47	1	685	31	0	0.55
Alves	2012	Brazil	mixed	Oral	C1772T	PB	40	88	0	1	39	0	85	3	<0.01
					G1790A	PB	40	88	2	1	37	81	7	0	0.70
Ruiz-Tovar	2012	Spain	Caucasian	Pancreatic	C1772T	PB	59	152	47	1	11	116	28	8	0.002
					G1790A	PB	59	152	54	2	3	142	10	0	0.68
Fu	2013	China	Asian	Cervical	C1772T	HB	518	553	467	49	2	492	60	1	0.55
					G1790A	HB	509	553	489	20	0	510	42	1	0.89
Ribeiro	2013	Portugal	Caucasian	Breast	C1772T	PB	96	74	74	21	1	61	7	4	0.001
					G1790A	PB	96	74	96	0	0	74	0	0	0.99
Mera-
Menendez	2013	Spain	Caucasian	Glottic
larynx	C1772T	HB	118	148	85	18	15	113	27	8	0.001
					G1790A	HB	111	139	107	4	0	130	9	0	0.69
Total					C1772T		10869	14289	8994	1568	307	12181	1897	211
					G1790A		7117	10442	6416	589	112	9922	494	26

W: wide type alleles (1772C or 1790G); M: mutant type alleles (1772 T or 1790A); HWE: Hardy-Weinberg Equilibrium; PB: population based; HB: hospital based.

Mixed: Caucasian and African-American; HNSCC: head and neck squamous cell carcinoma.

*Frequency of genotypes “AA + AG”; **Frequency of genotypes “TT + TC”.