Table 3.
Associations of uPA system components in tumour tissue specimens with disease-specific survival (DSS) and overall survival (OS) of patients with ccRCC (n = 112) assessed by multivariate Cox’s regression analysis
| Factor | No. cases | Disease-specific survival HR (95% CI) a | P | Overall survival HR (95% CI) a | P |
|---|---|---|---|---|---|
| Gender | |||||
| male | 65 | 1 | 1 | ||
| female | 47 | 0.93 (0.38-2.28) | 0.880 | 1.65 (0.79-3.45) | 0.179 |
| Age (years) | |||||
| ≤64 | 57 | 1 | 1 | ||
| >64 | 55 | 2.31 (0.89-5.99) | 0.085 | 2.52 (1.26-5.07) | 0.009 |
| Tumour stage | |||||
| pT1+2 | 87 | 1 | 1 | ||
| pT3+4 | 25 | 1.85 (0.73-4.69) | 0.192 | 1.17 (0.56-2.44) | 0.670 |
| Tumour grade | |||||
| G1+2 | 68 | 1 | 1 | ||
| G3+4 | 44 | 2.08 (0.83-5.19) | 0.118 | 1.61 (0.82-3.14) | 0.165 |
| uPA b | |||||
| low | 53 | 1 | 1 | ||
| high | 59 | 2.86 (1.07-7.67) | 0.037 | 1.28 (0.66-2.51) | 0.467 |
| uPAR b | |||||
| low | 55 | 1 | 1 | ||
| high | 57 | 4.70 (1.51-14.6) | 0.008 | 1.60 (0.80-3.23) | 0.185 |
| PAI-1 b | |||||
| low | 56 | 1 | 1 | ||
| high | 56 | 2.59 (0.95-7.08) | 0.064 | 1.71 (0.85-3.46) | 0.135 |
aHR: hazard ratio; 95% CI: 95% confidence interval of multivariate Cox’s regression analysis; uPA system factors were separately added to the base model consisting of gender, age, tumour stage and tumour grade.
bDichotomised into groups with high and low levels of uPA system factors by the median values.