Table 5.
Association of the combination of uPA system component levels in tumour tissue specimens with disease-specific survival (DSS) and overall survival (OS) in the subgroup of ccRCC patients with organ-confined tumours (tumour stage pT1+2, n = 87) assessed by multivariate Cox’s regression analysis
| Factor | No. cases | Disease-specific survival HR (95% CI) a | P | Overall survival HR (95% CI) a | P |
|---|---|---|---|---|---|
| uPA/uPAR b | |||||
| uPA and uPAR low | 35 | 1 | 1 | ||
| uPA and/or uPAR high | 52 | 9.83 (1.21-79.6) | 0.032 | 1.03 (0.45-2.37) | 0.942 |
| uPA/PAI-1 b | |||||
| uPA and PAI-1 low | 37 | 1 | 1 | ||
| uPA and/or PAI-1 high | 50 | 3.23 (0.79-13.1) | 0.101 | 1.30 (0.56-3.02) | 0.541 |
| uPAR/PAI-1 b | |||||
| uPAR and PAI-1 low | 35 | 1 | 1 | ||
| uPAR and/or PAI-1 high | 52 | 2.68 (0.67-10.8) | 0.164 | 1.39 (0.58-3.29) | 0.460 |
aHR: hazard ratio; 95% CI: 95% confidence interval of multivariate Cox’s regression analysis; combinations of uPA system factors were separately added to the base model consisting of gender, age and tumour grade.
bDichotomised into groups with high and low levels of uPA system factors by the medians.