Table 2.
Patient characteristics – validation cohort
| Patient | Age group | Follow-up time [months] | Creatinine at time of biopsy [mg/dl] | Creatinine at follow-up [mg/dl] | eGFR (MDRD) at time of biopsy [ml/min/1.73 m 2 ] | eGFR (MDRD) at follow-up [ml/min/1.73 m 2 ] | Proteinuria at time of biopsy [g/d] | Proteinuria at follow-up [g/d] | Histological diagnosis | SD/PD | Endpoint | IFTA | GS | II |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 5 | 4.60 | 6.67 | <20 | <20 | 4.8 | 2.0 | IGAN | Progressive | ESRD | Moderate | 4 | Moderate |
| 2 | 2 | 51 | 0.88 | 0.96 | >60 | >60 | 1.9 | 1.5 | IGAN | Stable | Moderate | 2 | Moderate | |
| 3 | 3 | 34 | 1.34 | 1.97 | 41.4 | 26.2 | 2.2 | 0.5 | LN IV | Stable | Moderate | 3 | Moderate | |
| 4 | 1 | 23 | 1.09 | 0.98 | >60 | >60 | 3.0 | 0.3 | LN IV | Stable | Moderate | 2 | Moderate | |
| 5 | 1 | 50 | 0.52 | 0.86 | >60 | >60 | 10.4 | 0.2 | LN IV | Stable | Moderate | 0 | Moderate | |
| 6 | 1 | 41 | 1.05 | 5.46 | >60 | <20 | 1.7 | 3.3 | IGAN | Progressive | ESRD | Moderate | 0 | None |
| 7 | 3 | 58 | 0.86 | 8.54 | >60 | <20 | 1.3 | 4.6 | MGN | Progressive | ESRD | Moderate | 0 | None |
| 8 | 4 | 31 | 1.13 | 2.84 | >60 | 22 | 2.5 | 2.8 | MGN | Progressive | 2xCrea | Moderate | 0 | None |
| 9 | 3 | 25 | 2.59 | 6.61 | 25.5 | <20 | NA | NA | FSGS | Progressive | ESRD | Severe | 4 | NA |
| 10 | 3 | 72 | 1.43 | 7.60 | 53.2 | <20 | NA | 5.2 | IGAN | Progressive | ESRD | Moderate | 0 | None |
| 11 | 3 | 40 | 1.10 | 0.78 | 52.4 | >60 | NA | 0.0 | IGAN | Stable | Moderate | 3 | Moderate | |
| 12 | 3 | 1 | 4.86 | 6.34 | <20 | <20 | 7.9 | 12.5 | IGAN | Progressive | ESRD | Severe | 4 | None |
| 13 | 3 | 23 | 1.62 | 1.59 | 44.3 | 45.1 | 4.8 | 0.8 | IGAN | Stable | Severe | 1 | Moderate | |
| 14 | 2 | 7 | 0.91 | 0.82 | >60 | >60 | 10.0 | 0.8 | IGAN | Stable | None | 0 | None | |
| 15 | 4 | 17 | 1.23 | 4.32 | 58.3 | <20 | 6.3 | 6.5 | IGAN | Progressive | 2xCrea | Moderate | 2 | None |
| 16 | 3 | 16 | 2.71 | 4.16 | 24.2 | <20 | 1.0 | 1.1 | IGAN | Stable | Severe | 3 | Severe | |
| Median | 50 | 28 | 1.18 | 3.50 | 3.0 | 1.5 | ||||||||
| Mean | 47 | 31 | 1.75 | 3.78 | 4.4 | 2.8 | ||||||||
| SD | 15 | 20 | 1.30 | 2.76 | 3.3 | 3.3 | ||||||||
| Median S | 46.5 | 28.4 | 1.1 | 0.97 | 3.0 | 0.6 | ||||||||
| Median P | 49.5 | 28 | 1.33 | 6.48 | 3.6 | 4.6 | ||||||||
| Mean S | 43.9 | 30.4 | 1.27 | 1.52 | 4.8 | 0.7 | ||||||||
| Mean P | 49.8 | 31.4 | 2.22 | 6.05 | 4.1 | 5.3 | ||||||||
| SD S | 12.9 | 16 | 0.67 | 1.15 | 3.9 | 0.5 | ||||||||
| SD P | 16.9 | 24.8 | 1.64 | 1.81 | 2.7 | 3.5 | ||||||||
| p-value | n.s. | n.s. | n.s. | <0.001 | n.s. | 0.01 |
Abbreviations see legend of Table 1.