Table 3.
Pathways enriched/depleted in differentially regulated genes correlating with CREDI and INSCO
| Pathways enriched/depleted in differentially regulated genes correlating with CREDI | ||
| Upregulated genes (n = 222) | ||
| Pathways | # Genes | P value |
| Hedgehog signaling pathway | 3 | 0.002 |
| Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade | 3 | 0.006 |
| Formyltetrahydroformate biosynthesis | 2 | 0.006 |
| PDGF signaling pathway | 6 | 0.006 |
| TGF-beta signaling pathway | 5 | 0.018 |
| Transcription regulation by bZIP transcription factor | 3 | 0.018 |
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | 3 | 0.027 |
| Ornithine degradation | 1 | 0.030 |
| Integrin signaling pathway | 5 | 0.040 |
| Serine glycine biosynthesis | 1 | 0.050 |
| Downregulated genes (n = 340) | ||
| Pathways | # genes | P value |
| ATP synthesis | 4 | 0.000 |
| FGF signaling pathway | 8 | 0.001 |
| EGF receptor signaling pathway | 8 | 0.002 |
| GABA-B_receptor_II_signaling | 4 | 0.004 |
| Alzheimer disease-amyloid secretase pathway | 5 | 0.006 |
| T cell activation | 6 | 0.006 |
| Endogenous_cannabinoid_signaling | 3 | 0.007 |
| Histamine H1 receptor mediated signaling pathway | 4 | 0.007 |
| Metabotropic glutamate receptor group II pathway | 4 | 0.009 |
| B cell activation | 5 | 0.010 |
| Axon guidance mediated by netrin | 3 | 0.012 |
| Endothelin signaling pathway | 5 | 0.015 |
| Oxytocin receptor mediated signaling pathway | 4 | 0.016 |
| Thyrotropin-releasing hormone receptor signaling pathway | 4 | 0.018 |
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | 4 | 0.018 |
| Cholesterol biosynthesis | 2 | 0.018 |
| Metabotropic glutamate receptor group I pathway | 3 | 0.020 |
| 5HT2 type receptor mediated signaling pathway | 4 | 0.025 |
| Succinate to proprionate conversion | 1 | 0.031 |
| VEGF signaling pathway | 4 | 0.032 |
| 5HT1 type receptor mediated signaling pathway | 3 | 0.033 |
| Angiogenesis | 7 | 0.033 |
| Inflammation mediated by chemokine and cytokine signaling pathway | 9 | 0.037 |
| PDGF signaling pathway | 6 | 0.042 |
| DNA replication | 2 | 0.044 |
| Cell cycle | 2 | 0.048 |
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | 6 | 0.050 |
| Pathways enriched/depleted in differentially regulated genes correlating with INSCO | ||
| Upregulated genes (n = 150) | ||
| Pathways | # Genes | P value |
| Chorismate biosynthesis | 1 | 0.000 |
| Nicotinic acetylcholine receptor signaling pathway | 3 | 0.033 |
| Mannose metabolism | 1 | 0.049 |
| Downregulated genes (n = 135) | ||
| Pathways | # Genes | P value |
| mRNA splicing | 2 | 0.002 |
| General transcription by RNA polymerase I | 2 | 0.007 |
| PLP biosynthesis | 1 | 0.013 |
| Leucine biosynthesis | 1 | 0.013 |
| Alanine biosynthesis | 1 | 0.013 |
| Vitamin B6 metabolism | 1 | 0.019 |
| Valine biosynthesis | 1 | 0.019 |
| Isoleucine biosynthesis | 1 | 0.019 |
| PDGF signaling pathway | 4 | 0.019 |
| Serine glycine biosynthesis | 1 | 0.031 |
| Histamine H1 receptor mediated signaling pathway | 2 | 0.037 |
| p53 pathway feedback loops 2 | 2 | 0.044 |
| Apoptosis signaling pathway | 3 | 0.045 |
Biological pathways being enriched or depleted with respect to the set of significantly correlated genes were analyzed using the PANTHER (Protein ANalysis THrough Evolutionary Relationships) Classification System. # genes … number of genes.