Table 4.
Univariate and multivariate logistic regression analysis of risk factors associated with 30-day mortality in patients with Acinetobacter calcoaceticus-Acinetobacter baumannii complex bacteremia.
Univariate analysis | Multivariate analysis | |||||
---|---|---|---|---|---|---|
Risk factor | Survived (n = 101) | Died (n = 46) | OR (95% CI) | p-value | OR (95% CI) | p-value |
Age, mean ± (SD) | 51 (17) | 56 (12) | 1.02 (1.00–1.05) | 0.06 | ||
Sex, female | 54 (54) | 14 (30) | 0.38 (0.18–0.80) | 0.01 | 0.24 (0.08–0.75) | 0.01 |
A. baumannii | 74 (73) | 42 (91) | 3.83 (1.26–11.7) | 0.02 | ||
Source: | ||||||
Catheter | 76 (75) | 26 (57) | 0.43 (0.21–0.89) | 0.02 | ||
Respiratory | 3 (3) | 11 (24) | 10.27 (2.71–38.96) | < 0.01 | ||
Primary | 10 (10) | 1 (2) | 0.20 (0.03–1.63) | 0.13 | ||
Healthcare-associated | 46 (46) | 39 (85) | 6.67 (2.72–16.3) | < 0.01 | ||
Multidrug resistance | 54 (54) | 43 (94) | 12.48 (3.63–42.85) | < 0.01 | ||
Received appropriate therapy | 91 (90) | 25 (54) | 0.13 (0.06–0.31) | < 0.01 | 0.13 (0.04–0.44) | < 0.01 |
Days to appropriate therapy, median (range) | 1 (0–13)a | 1 (0–5)b | 0.84 (0.64–1.12) | 0.24 | ||
Mechanical ventilation | 16 (16) | 36 (78) | 19.13 (7.93–46.15) | < 0.01 | 20.7 (6.8–62.9) | < 0.01 |
Prior antibiotic days, median (range) | 0 (0–42) | 12 (0–105) | 1.09 (1.05–1.13) | < 0.01 | ||
Age-adjusted Charlson comorbidity score, median (range) | 3 (0–12) | 5 (0–11) | 1.16 (1.03–1.31) | 0.01 | ||
Current immunosuppression | 46 (46) | 33 (72) | 3.04 (1.43–6.44) | < 0.01 | ||
Diabetes mellitus | 27 (27) | 21 (46) | 2.3 (1.11–4.77) | 0.03 | ||
Renal dysfunction | 35 (35) | 34 (74) | 5.34 (2.46–11.6) | < 0.01 | 4.21 (1.46–12.1) | < 0.01 |
Liver dysfunction | 23 (23) | 27 (59) | 4.82 (2.28–10.19) | < 0.01 |
Data are No. (%) unless otherwise specified
OR, odds ratio; CI, confidence interval; SD, standard deviation; ICU, intensive care unit
For the 91 survivors who received appropriate therapy
For the 25 non-survivors who received appropriate therapy