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Mutation specific simulated APD and mutation specific mean QTc in patients.
| Mutation | APD basal Δ(WT-mut), msec | APD Beta Δ(WT-mut), msec | APD alpha + beta Δ(WT-mut), msec | Mean Patient QTc msec (mean±SDM) |
|---|---|---|---|---|
| G168R | 306 (56) | 408 (177) | 345 (133) | 480±40 |
| S225L | 290 (40) | 396 (165) | 370 (158) | 490±50 |
| R243C | 300 (50) | 420 (189) | 434 (222) | 490±60 |
| V254M | 315 (65) | 443 (212) | 430 (218) | 500±50 |
| R555C | 300 (50) | 263 (32) | 230 (18) | 490±20 |
