Table 2.

Echocardiography analysis of Sham and ACF mice.

Tail Cuff Blood Pressure and Echocardiographic Analysis
	Sham	ACF
Tail-Cuff Blood Pressure (conscious)
n=	5	8
HR [BPM]	635 ± 14	575 ± 23
Systolic [mmHg]	121 ± 6	127 ± 6
Diastolic [mmHg]	100 ± 4	105 ± 5
MAP [mmHg]	107 ± 4	112 ± 5
Pulse Pressure [mmHg]	21 ± 3	22 ± 2
M-mode (conscious)
n=	16	20
LVID;d [mm]	3.35 ± 0.06	4.6 ± 0.09***
LVPWT;d [mm]	0.86 ± 0.02	0.85 ± 0.02
LVID;s [mm]	1.79 ± 0.06	2.73 ± 0.1***
LVPWT;s [mm]	1.41 ± 0.03	1.46 ± 0.04
FS [%]	46.6 ± 1.3	41 ± 1.4**
LVID;d/PWT;d	3.95 ± 0.13	5.48 ± 0.19***
LAD [mm]	2.42 ± .07	3.30 ± 0.10***
Pulsed Wave Doppler
Ao Vel [mm/s]	770 ± 20	1296 ± 58***
MV E [mm/s]	690 ± 23	922 ± 22***
MV A [mm/s]	496 ± 26	700 ± 27***
MV Decel Time [ms]	25 ± 0.6	29.7 ± 0.7***
MV E/A	1.42 ± 0.04	1.33 ± 0.03
MV e′ [mm/s]	16 ± 1.1	15.7 ± 0.7
MV a′ [mm/s]	20.9 ± 1.2	23.4 ± 1.3
e’/a’	0.77 ± 0.04	0.69 ± 0.03
E/e’	45.3 ± 2.5	60.5 ± 2.5***

Significant vs. Sham at

^**p< 0.01

^***P<0.001

Abbreviations: HR, heart rate: BPM, beats per minute: LV, left ventricle: LVIDd, LV internal diameter diastole: LVPWTd, LV posterior wall thickness diastole ; LVIDs, LV internal diameter systole; LVWTs, LV posterior wall thickness systole; FS, fractional shortening percent; Eccentricity: LVIDd/PWTd; LAD, left atrial diameter; Ao Vel, aortic velocity; MV E, mitral valve E-wave velocity; MV A, mitral valve A-wave velocity; MV e’, septal mitral valve annular tissue velocity; MV a’, septal mitral valve annular tissue velocity