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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Bioorg Med Chem. 2014 Dec 10;23(3):532–547. doi: 10.1016/j.bmc.2014.12.006

Scheme 1.

Scheme 1

Reagents and conditions: (a) R5CHO, n-BuLi, THF, −78 °C, 2h; (b) Et3SiH, TFA, DCM, overnight, rt; (c) R2COCl, Et3N, THF, 15 min, rt or (d) R2COOH, EDAC, DMAP, Et3N, DMF/DCM (3/1, v/v), 2h, rt or (e) TFAA, DCM, 30 min, rt. aNot applicable.